Dihydrotestosterone, Active Androgen Metabolites, and Related Pathology

    January 2003
    Guido Verhoeven
    Image of study
    TLDR Dihydrotestosterone (DHT) and its active metabolites play a key role in various diseases, and the development of 5α-reductase inhibitors can help treat these conditions.
    The document "Dihydrotestosterone, Active Androgen Metabolites and Related Pathology" from 2002 discussed the role of Dihydrotestosterone (DHT) and its active metabolites in various pathologies. It highlighted the existence of two genes/two enzymes for Steroid 5α-reductase, an enzyme that plays a crucial role in the conversion of testosterone to DHT. The document also discussed Steroid 5α-reductase type 2 deficiency and its implications. It further explored the connection between benign prostatic hyperplasia and the development of 5α-reductase inhibitors. The document also touched upon other applications of 5α-reductase inhibitors and posed remaining questions in the field for future research.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 134 results

    Similar Research

    6 / 1000+ results
      Basics of Androgen Synthesis and Action

      research Basics of Androgen Synthesis and Action

      35 citations, May 2022 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”
      Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.
      Clinical Biochemistry of Dihydrotestosterone

      research Clinical Biochemistry of Dihydrotestosterone

      50 citations, February 2013 in “Annals of Clinical Biochemistry”
      Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
      Clinical Use of 5α-Reductase Inhibitors

      research Clinical Use of 5α-Reductase Inhibitors

      3 citations, January 2001 in “Cambridge University Press eBooks”
      Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
      Androgen Effects in Mammals

      research Androgen Effects in Mammals

      7 citations, January 2003 in “Elsevier eBooks”
      Testosterone is crucial for development, growth, and various body functions in mammals.
      Finasteride

      research Finasteride

      10 citations, June 2010 in “Expert Opinion on Drug Metabolism & Toxicology”
      Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.