Cutaneous Manifestations and Hormonal Changes Among Polycystic Ovary Syndrome Patients at a Tertiary Care Center

    December 2021 in “ Cureus ”
    Yara E Aljefri, Rana A Alahmadi, Rakan S Alajmi, Taif A Alkhamisi, Hadeel A Maaddawi, Ali Alraddadi, Awadh Alamri
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    TLDR Most women with Polycystic Ovary Syndrome (PCOS) have skin issues like excessive hair, acne, or hair loss. Hormone imbalances are common, and age, certain hormones, and hormone ratios can predict acne. Obesity, infertility, and high cholesterol are also common in these women.
    The study involved 447 female patients with Polycystic Ovary Syndrome (PCOS), finding that 68% had at least one skin manifestation, most commonly hirsutism (47.3%), acne vulgaris (40.6%), and androgenic alopecia (20.3%). Hormonal abnormalities were common, with 49.1% having raised luteinizing hormone (LH) levels and 35.5% having a raised LH/follicle-stimulating hormone (FSH) ratio. Age, FSH, and LH/FSH ratio were significant predictors for acne vulgaris. The most common comorbidities were obesity (44.20%), infertility (25.70%), and dyslipidemia (17%). The study concluded that skin manifestations are prevalent in PCOS patients and play a significant role in diagnosis. However, no significant associations were found between androgenic alopecia and measured fasting blood glucose, HbA1c, or other hormones.
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