Computational Derivation of a Molecular Framework for Hair Follicle Biology from Disease Genes

    November 2017 in “ Scientific Reports ”
    Rachel K. Severin, Xinwei Li, Kun Qian … Lynn Petukhova
    Studysummary This study compiled an archive of 684 genes associated with monogenic hair disorders, identifying previously unrecognized components of Hippo signaling and proposing a new biologically-grounded disease taxonomy.
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    Research cited in this study 9

    1. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    2. Genetic Prediction of Male Pattern Baldness PLoS Genetics · 2017
    3. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
    4. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    5. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    6. FGF5 Is a Crucial Regulator of Hair Length in Humans Proceedings of the National Academy of Sciences of the United States of America · 2014
    7. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update Journal of Dermatological Science · 2012
    8. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    9. The Biology of Hair Follicles The New England Journal of Medicine · 1999

    Related research 1

    1. Computational Derivation of a Molecular Framework for Hair Follicle Biology from Disease Genes Scientific Reports · 2017