Comprehensive Transcriptome Profiling Between Balding and Non-Balding Scalp of Female Pattern Hair Loss in Asian

February 2024 in “ Research Square (Research Square) ”

Soon Re Kim, Yun Ji Kim, Ju-Hee Kim, Su Na Kim, Won Serk Park, Se Hwan Kim, Jun‐Won Chung, Mi Soo Choi, Myung‐Hwa Kim, Byung Cheol Park

Female Pattern Hair Loss FPHL HOXB13 SFRP2 PTGDS CXCR3 SFRP4 SOD3 DCN next-generation sequencing biomarkers bald hair follicles non-bald hair follicles

TLDR The research suggests that SFRP2 and PTGDS proteins might be indicators of female pattern hair loss and could contribute to hair loss.

The study aimed to identify molecular biomarkers associated with Female Pattern Hair Loss (FPHL) by analyzing the genetic differences between bald and non-bald hair follicles from 18 FPHL patients. The researchers used next-generation sequencing techniques and found that genes HOXB13, SFRP2, PTGDS, CXCR3, SFRP4, SOD3, and DCN were significantly upregulated in bald hair follicles. Particularly, SFRP2 and PTGDS were consistently highly expressed in all bald hair follicles and their elevated protein levels were confirmed. The study concluded that SFRP2 and PTGDS could be potential biomarkers for FPHL and may play a role in inducing hair loss in this condition.

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