TLDR PGA fiber-reinforced collagen sponges improve hair growth and skin structure.
The study explored a modified hair reconstitution method using a collagen sponge scaffold reinforced with polyglycolic acid (PGA) fiber in a murine model. Traditional methods using silicone chambers faced issues like leakage and inconsistent hair growth. The research found that while conventional collagen sponges disrupted normal hair follicle formation, the PGA fiber-reinforced collagen sponges effectively supported the proper restructuring of skin and hair follicles. This indicated the potential of PGA fiber-containing collagen sponges for improving hair reconstitution in both research and clinical settings.
854 citations
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February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
949 citations
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January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
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November 2014 in “Elsevier eBooks” Future research should focus on making bioengineered skin that completely restores all skin functions.
216 citations
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February 2022 in “Nanomaterials” Electrospun gelatin-based nanofiber dressings are promising for wound healing due to their effective healing properties and ability to protect against infections.
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December 2010 in “Elsevier eBooks” Cell transplantation faces challenges in genitourinary reconstruction, but alternative tissue sources and microencapsulation show promise.
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March 2021 in “Materials Today Bio” Scaffold-based strategies show promise for regenerating hair follicles and teeth but need more research for clinical use.
82 citations
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May 2020 in “International Journal of Molecular Sciences” Injectable biomaterials can effectively regenerate dental tissues.
