Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride

September 1998 in “ The Journal of Steroid Biochemistry and Molecular Biology ”

Kenneth P. Ellsworth, B. Azzolina, George Cimis, Herbert G. Bull, Gerald F. Harris

5alpha-Reductase finasteride 5aR inhibitors isozymes mechanism-based inhibition Propecia

TLDR Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

The study cloned, expressed, and characterized types 1 and 2 5alpha-Reductase in rhesus macaques and found that finasteride inhibits the enzyme's activity in a mechanism-based manner. This suggests that rhesus macaques can be used as a model to evaluate the pharmacological properties of finasteride and other 5aR inhibitors. The study also identified two isozymes of human 5aR and found evidence for mechanism-based inhibition by finasteride. The researchers suggest that further research is needed to understand the effects of 5aR1 inhibitors.

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14 / 14 results

research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

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research Critical Developmental Periods for Effects on Male Rat Genitalia Induced by Finasteride, a 5α-Reductase Inhibitor

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1 / 1 results

research Determination of Rat 5α-Reductase Type 1 Isozyme Activity and Its Inhibition by Novel Steroidal Oxazolines

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New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.