Finasteride: A slow-binding 5.alpha.-reductase inhibitor
June 1993
in “Biochemistry”
TLDR Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
This document from 1993 investigates the interaction between finasteride and 5-alpha-reductase, an enzyme involved in the conversion of testosterone to dihydrotestosterone (DHT). The study found that the association rate constant (kon) between finasteride and 5-alpha-reductase was much lower than expected, which has implications for accurately determining the equilibrium dissociation constant (K₁) and evaluating the potency of inhibitors. The study also investigated the stability of the enzyme and the effect of temperature and pH on the interaction.
View this study on pubs.acs.org →
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research Finasteride: A slow-binding 5.alpha.-reductase inhibitor
Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.