This study investigated the levels of cell-free DNA in the serum of 20 patients with hidradenitis suppurativa (HS) compared to 12 healthy controls. The results showed that HS patients had significantly higher mean serum levels of cell-free DNA (697.4 μg/ml ± 590.2) compared to the control group (307.8 μg/ml ± 237.6), with a P-value of <0.0379. Cell-free DNA levels positively correlated with C-reactive protein (CRP), a marker of disease activity in HS, but did not correlate with age or BMI. This suggests that cell-free DNA could be a potential biomarker for HS, reflecting systemic inflammation and possibly linked to the innate immune system's response. Further research is needed to explore its role in disease severity and progression.
2 citations,
December 2022 in “The Journal of Dermatology” This study investigated the levels of cell-free DNA in the serum of 20 patients with hidradenitis suppurativa (HS) compared to 12 healthy controls. The results showed that HS patients had significantly higher mean serum levels of cell-free DNA (697.4 μg/ml ± 590.2) compared to the control group (307.8 μg/ml ± 237.6), with a P-value of <0.0379. Cell-free DNA levels positively correlated with C-reactive protein (CRP), a marker of disease activity in HS, but did not correlate with age or BMI. This suggests that cell-free DNA could be a potential biomarker for HS, reflecting systemic inflammation and possibly linked to the innate immune system's response. Further research is needed to explore its role in disease severity and progression.
9 citations,
August 2021 in “Experimental dermatology” Hidradenitis suppurativa is a skin disease caused by the breakdown of the skin's natural immune barriers, especially around hair follicles.
33 citations,
June 2020 in “Journal of Clinical Investigation” Stress in hair follicle stem cells causes inflammation in a chronic skin condition through a specific immune response pathway.
