TLDR Patients with hidradenitis suppurativa have higher levels of cell-free DNA in their blood.
This study found that patients with hidradenitis suppurativa (HS) have significantly elevated levels of cell-free DNA in their serum compared to healthy controls. The research involved 20 HS patients, mostly with moderate to severe disease, and 12 healthy individuals. The mean serum level of cell-free DNA in HS patients was 697.4 μg/ml, significantly higher than the 307.8 μg/ml observed in healthy controls (P < 0.0379). Additionally, cell-free DNA levels positively correlated with C-reactive protein (CRP), a marker of inflammation, but not with age or BMI. This suggests that cell-free DNA could be a potential biomarker for HS severity, warranting further investigation in larger studies.
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December 2022 in “The Journal of Dermatology” Patients with hidradenitis suppurativa have higher levels of cell-free DNA in their blood.
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August 2021 in “Experimental dermatology” Hidradenitis suppurativa is a skin disease caused by the breakdown of the skin's natural immune barriers, especially around hair follicles.
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