Cell Viability and Hair Growth Effect on 3T3-L1 Cells of Ethanol Extract from Calendula Officinalis L. Flower, Phellinus Linteus Fruit Body, and Houttuynia Cordata Thunb. Whole Plant

December 2017 in “ Korean Journal of Medicinal Crop Science ”

Seong Woo Jin, Kyoung Sun Seo, Young Woo Koh, Kyeong Won Yun, Kyung Je Kim, Hae Shin Je, Seung Bin Im, Kwang Sang Kim, Min Sook Kim, Byung Jo Yu

Calendula officinalis Phellinus linteus Houttuynia cordata ethanol extract hair follicle dermal papilla cells HFDPC 3T3-L1 cells adipogenesis hair regeneration marigold black hoof mushroom fish mint fat cell differentiation hair growth

Studysummary This study found that 70% ethanol extract of Houttuynia cordata promoted hair growth in laboratory cell models, suggesting potential use in developing hair care products.

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The study investigated the effects of 70% ethanol extracts from Calendula officinalis flowers, Phellinus linteus fruit bodies, and Houttuynia cordata whole plants on cell viability and hair growth. The extracts were tested on CCD-986 cells, hair follicle dermal papilla cells (HFDPC), and 3T3-L1 cells. While most extracts were cytotoxic to CCD-986 cells, they were not harmful to HFDPC. Notably, the H. cordata extract promoted hair growth by enhancing adipogenesis in 3T3-L1 cells, which is linked to hair regeneration through the secretion of platelet-derived growth factor. The findings suggested that these plant extracts could be beneficial in developing hair care products.

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