Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series

    April 2023 in “ American Journal of Dermatopathology ”
    Shane Smith, Navitha Woddor, David S. Cassarino … Victor E. Nava
    Studysummary This study suggests that central centrifugal cicatricial alopecia may involve a CD4-predominant T-cell process with potential PD1/PDL1 pathway involvement, indicated by increased caspase 3 expression and loss of PDL1.
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    Research cited in this study 10

    1. Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases International Journal of Molecular Sciences · 2020
    2. Variant PADI3 in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019
    3. Cicatricial Alopecia Research Foundation Meeting, May 2016: Progress Towards the Diagnosis, Treatment, and Cure of Primary Cicatricial Alopecias Experimental Dermatology · 2018
    4. Primary Cicatricial Alopecia Journal of The American Academy of Dermatology · 2016
    5. Central Centrifugal Cicatricial Alopecia: Challenges and Solutions Clinical, Cosmetic and Investigational Dermatology · 2016
    6. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013
    7. A Comprehensive Approach to Hair Pathology of Horizontal Sections The American Journal of Dermatopathology · 2013
    8. Hair Breakage as a Presenting Sign of Early or Occult Central Centrifugal Cicatricial Alopecia Archives of Dermatology · 2012
    9. A Detective Look at Hair Biopsies from African-American Patients British Journal of Dermatology · 2012
    10. Investigation of the Hair Follicle Inner Root Sheath in Scarring and Non-Scarring Alopecia Journal of Cutaneous Pathology · 2007