Differentiation Stage-Specific Use of Cap-Independent and Cap-Dependent Translation Initiation in Hematopoiesis

    September 2025
    Michael Mazzola, Ting Zhao, Anna Kiem … David T Scadden
    Studysummary In this study, researchers observed that IRES/Cap translation initiation increased during caloric stress across cell differentiation states and also unexpectedly rose during normal differentiation processes in mice, with lower IRES/Cap being linked to higher stem cell potential, mediated by PTBP1, a RNA processing protein.
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    Research cited in this study 1

    1. Emerging Roles of Transit-Amplifying Cells in Tissue Regeneration and Cancer Wiley Interdisciplinary Reviews-Developmental Biology · 2017