Visual Imaging of Calcium Ion Distribution in Acetone and Tape Stripping Damaged Canine Epidermis

June 2010 in “ Journal of Veterinary Clinics ”

Won‐Seok Oh, Keun‐Woo Lee, Tae‐Ho Oh

calcium ion epidermis skin barrier acetone tape stripping fluorescent microscope Calcium Green-1 hair follicles

TLDR The method visualized calcium ions in damaged canine skin, showing potential for studying skin recovery.

This study aimed to establish a model for canine skin barrier disruption and observe calcium ion distribution in damaged skin. Using a fluorescent microscope and Calcium Green-1, researchers visualized calcium ion distribution in canine epidermis after damage from clipping, acetone, and tape stripping. They found that acetone damage resulted in radiant gradations in the epidermis and hair follicles that disappeared after 48 hours, while tape stripping caused more radiant gradations that stabilized after 48 hours. The method allowed visualization of calcium ions in frozen tissue, suggesting its potential usefulness in studying calcium ion roles in epidermal barrier recovery, though further methodological improvements were needed for accurate quantitative data.

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