Emerging Role of Baricitinib in Dermatology Practice: All We Need to Know

January 2023 in “ Indian Dermatology Online Journal ”

S. Dogra, Shikha Shah, Ayush Sharma, Seema Chhabra, Tarun Narang

baricitinib Janus Kinase inhibitor JAK-1 JAK-2 alopecia areata atopic dermatitis pro-inflammatory cytokines

TLDR Baricitinib effectively treats certain skin conditions but may have serious side effects.

Baricitinib, a Janus Kinase inhibitor targeting JAK-1 and JAK-2, demonstrated efficacy in treating severe alopecia areata and moderate-severe atopic dermatitis in adults by downregulating pro-inflammatory cytokines. While its use in other dermatological conditions showed promise, dermatologists needed to be cautious of its potential infectious, thrombotic, cardiovascular, and malignant side effects. The long-term safety data in dermatology were insufficient, as most safety information was derived from rheumatology. Further research was necessary to better understand its safety and efficacy in dermatological applications.

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research Integrated Safety Analysis of Baricitinib in Adults With Severe Alopecia Areata From Two Randomized Clinical Trials

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Baricitinib for severe alopecia areata is generally safe, with common side effects like infections and acne, and low rates of serious complications.

research The Efficacy and Safety of JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis of Prospective Studies

37 citations , August 2022 in “Frontiers in pharmacology”

Oral JAK inhibitors are effective and safe for treating alopecia areata but may need ongoing use to keep results.

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148 citations , March 2022 in “The New England Journal of Medicine”

Baricitinib was effective in treating alopecia areata in two major trials.

research Application of Baricitinib in Dermatology

14 citations , March 2022 in “Journal of inflammation research”

Baricitinib shows promise as a new treatment for certain skin conditions like alopecia areata.

Efficacy and Safety of the Oral Janus Kinase Inhibitor Baricitinib in the Treatment of Adults with Alopecia Areata: Phase 2 Results from a Randomized Controlled Study

research Efficacy and Safety of the Oral Janus Kinase Inhibitor Baricitinib in the Treatment of Adults with Alopecia Areata: Phase 2 Results from a Randomized Controlled Study

66 citations , June 2021 in “Journal of The American Academy of Dermatology”

Baricitinib is effective and safe for treating severe alopecia areata.

research A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata

40 citations , June 2021 in “Clinical, cosmetic and investigational dermatology”

JAK inhibitors show promise in effectively treating hair loss from alopecia areata.

research Treatment of Pediatric Alopecia Areata: A Systematic Review

48 citations , April 2021 in “Journal of the American Academy of Dermatology”

Topical corticosteroids are the best initial treatment for children's alopecia areata.

‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

research ‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

30 citations , September 2020 in “Journal of Patient-Reported Outcomes”

Alopecia Areata (AA) causes significant emotional distress, including feelings of embarrassment, depression, and anxiety, and impacts social interactions and daily activities.

research Benefit and Risk Profile of Tofacitinib for the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis

54 citations , September 2019 in “Journal of the European Academy of Dermatology and Venereology”

Tofacitinib is somewhat effective for alopecia areata, but more research is needed on its safety and long-term effects.

research Alopecia Areata: A Review of Disease Pathogenesis

191 citations , May 2018 in “British journal of dermatology/British journal of dermatology, Supplement”

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

research Alopecia Areata: Overview and Insights from January 2018

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

research JAK Inhibitors in Dermatology: The Promise of a New Drug Class

355 citations , January 2017 in “Journal of the American Academy of Dermatology”

JAK inhibitors show promise for treating skin conditions like eczema, hair loss, and psoriasis.

research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

184 citations , February 2015 in “EBioMedicine”

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

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Baricitinib, approved for alopecia areata, might be considered for treating receding hairlines. The discussion is about the possibility of an over-the-counter topical version for androgenic alopecia.

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research Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib

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Oral and topical tofacitinib can help regrow hair in people with severe alopecia areata.