Axolotl-derived decellularized skin ECM as a pro-regenerative scaffold for attenuating fibrotic wound healing

The study investigates the use of axolotl-derived decellularized extracellular matrix (A-dECM) as a scaffold to enhance regenerative healing and reduce fibrosis in burn wounds. In vitro and in vivo experiments demonstrated that A-dECM supports cell proliferation, accelerates wound closure, and improves skin architecture by reducing inflammatory and fibrotic markers. A-dECM modulates the immune environment by promoting M2 macrophage signals, leading to enhanced re-epithelialization and organized collagen remodeling. The study concludes that A-dECM has potential as a therapeutic scaffold for skin regeneration, although challenges such as scalable production and regulatory approval need to be addressed before clinical application.