Autoimmune Alopecia/Alopecia Areata

    January 2024
    Andrea Combalía
    TLDR New drugs, baricitinib and ritlecitinib, are effective for severe alopecia areata.
    Alopecia areata (AA) is an autoimmune disorder characterized by sudden, patchy hair loss, affecting 2% of the population. Diagnosis is mainly clinical, with trichoscopy and skin biopsy as supportive tools. While mild cases may resolve on their own, severe cases often require treatment. Traditional treatments include topical and oral steroids, but they have variable success and potential side effects. Recently, the FDA approved JAK inhibitors, baricitinib and ritlecitinib, as effective treatments for severe AA. These drugs target the JAK-STAT pathway, crucial in AA's pathogenesis, and have shown positive results in clinical trials. Both are well-tolerated, but further research is needed to confirm their long-term safety and efficacy. The treatment options for AA are expanding with ongoing trials for new targeted therapies.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community AGA evaluation and first steps - BEGINNER MEGAPOST

      in Chat  79 upvotes 1 year ago
      The conversation discusses androgenic alopecia (AGA) and its treatments, focusing on finasteride, minoxidil, and ketoconazole shampoo. Finasteride is recommended as essential for preventing further hair loss.

      community 17M biotin and minoxidil hair regrowth progress

      in Progress Pictures  83 upvotes 2 years ago
      A user's hair regrowth journey using biotin and minoxidil after initial treatments with Nizoral shampoo and Ketoconazole serum didn't work. The comments suggest the hair loss might not be male pattern baldness (MPB), but possibly Alopecia Areata, an autoimmune disorder, and recommend getting a second opinion and considering other treatments like corticosteroids.

      community To anyone that is still not seeing results on the big 3…

      in Treatment  109 upvotes 3 years ago
      User redh0t12 suggests using a derma pen for hair regrowth, as it helped them after using finasteride and minoxidil. Others discuss their experiences with various treatments, including derma rolling, oral and topical minoxidil, and finasteride, with mixed results.

      community When are we getting a cure to hair loss?

      in Chat 2 years ago
      Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

    Related Research

    1 / 1 results