Reply by the Authors

    September 2004 in “ Urology
    G.L. Andriole
    TLDR Dutasteride may help prevent prostate cancer, but more research is needed.
    The authors acknowledged the limitations of their study design, which did not definitively prove the effectiveness of dutasteride in preventing prostate cancer. However, they highlighted the significant impact of dutasteride compared to finasteride, attributing this to dutasteride's ability to inhibit both type 1 and type 2 5-alpha-reductase, enzymes present in some prostate cancers. This finding suggested the need for further research on dutasteride's potential in cancer prevention. The document also compared the PCPT and REDUCE studies, noting differences in study duration, subject numbers, and enzyme inhibition.
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