Atypical Clinical Presentation of Primary and Secondary Cutaneous Follicle Center Lymphoma on the Head Characterized by Macular Lesions

    July 2016 in “ Journal of The American Academy of Dermatology ”
    Cesare Massone, Regina Fink‐Puches, Lorenzo Cerroni
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    TLDR Some skin lymphomas can look like common skin issues and need careful testing to diagnose correctly.
    The document detailed a study of 13 patients diagnosed with primary cutaneous follicle center lymphoma (pcFCL, 11 patients) or secondary cutaneous follicle center lymphoma (FCL, 2 patients) who presented with atypical macular lesions on the scalp and forehead. These lesions were initially misdiagnosed as conditions like rosacea and alopecia due to their unusual appearance. Histologic examination was crucial for the correct diagnosis of FCL. The study underscored the need for dermatologists to recognize such atypical presentations to avoid misdiagnosis and provide appropriate treatment. Radiotherapy was effective in some patients, while Rituximab was suggested as an alternative, and a watchful waiting approach was also considered. The study was limited by its small sample size and retrospective nature.
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