Antiaging Activity of Peptide Identified from Fermented <i>Trapa Japonica</i> Fruit Extract in Human Dermal Fibroblasts

    Jin Jang, Min-Kyung Kim, Gun He Nam, Young‐Min Kim, Sang Moon Kang, Kee‐Young Lee, Young-Joon Park
    TLDR A peptide from fermented Trapa japonica fruit may help reduce skin aging.
    The study demonstrated that a newly synthesized peptide (PEP) from fermented Trapa japonica fruit extract (FTJ) showed promising antiaging effects on human dermal fibroblasts. PEP, along with TJE and FTJ, enhanced cell viability and collagen synthesis while inhibiting TNF-α-induced mRNA expression of matrix metalloproteinases (MMPs). PEP also significantly improved wound recovery in HaCaT cells and exhibited antiaging effects in a clinical study. These findings suggested that PEP could be a potential ingredient for skin antiaging cosmetic products.
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