Anti-EGFR Mechanism of Action: Antitumor Effect and Underlying Cause of Adverse Events

    April 2006 in “ PubMed ”
    Heinz‐Josef Lenz
    Studysummary This review summarizes adverse events associated with EGFR-targeting cancer therapies, such as skin rashes and lung disease, and reports no new clinical results.
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    Research cited in this study 2

    1. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995
    2. Immunolocalization of Epidermal Growth Factor Receptors in Normal Developing Human Skin Journal of Investigative Dermatology · 1990