Anti-Androgenic Therapy as Chemoprevention of Prostate Cancer

January 2004 in “ Medicina de Familia SEMERGEN ”

D. Subirá Ríos, E. Alonso Sandoica, Juan Ignacio Martínez‐Salamanca, J. Jara Rascón, C. Hernández Fernández

5-alpha-reductase inhibitors finasteride anti-androgenic therapy prostatic intraepithelial neoplasm benign prostatic hyperplasia prostatic atrophy Propecia

TLDR Finasteride may help prevent prostate cancer.

The article discussed the potential role of 5-alpha-reductase inhibitors, such as finasteride, in the prevention of prostate cancer. It presented a case of prostatic intraepithelial neoplasm (PIN) treated with finasteride for benign prostatic hyperplasia, which resulted in prostatic atrophy upon biopsy. The study explored the mechanism of anti-androgenic therapy in treating dysplasias and reviewed existing literature on its potential to reduce prostate cancer risk.

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6 / 1000+ results

community Finasteride affects both 5a reductase and 5b reductase

7 upvotes 6 years ago

Finasteride not only inactivates the 5a reductase enzyme but also affects the 5b reductase enzyme in a dose-dependent manner, which can impact sexual behavior and brain activity. The user experienced significant hair regrowth and side effects on 1mg of finasteride, which diminished after reducing the dose to 0.5mg, leading to no side effects and further hair improvement.

community From the research study: "Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia" - G. Bartsch, R.S. Rittmaster, H. Klocker (2002) in the "World Journal of Urology".

in Research/Science 23 upvotes 3 years ago

Dutasteride is a stronger 5AR inhibitor than finasteride and can significantly lower DHT levels. Reduced doses of dutasteride may lower side effects.

community Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy

in Research/Science 2 upvotes 1 year ago

Topical androgen receptor antagonists may not be necessary if 5-AR inhibitors like finasteride or dutasteride effectively reduce DHT levels. Combining a 5-AR inhibitor with a topical androgen antagonist could potentially enhance treatment, but oral use of androgen antagonists is too risky due to severe side effects.

community A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle

in Chat 1 upvotes 10 months ago

The conversation discusses the need for a localized 5-alpha reductase inhibitor that only affects the scalp without systemic side effects, similar to pyrilutamide's approach. Current treatments like topical liposomal finasteride and dutasteride are mentioned, but concerns about their systemic effects and lack of research are highlighted.

community Finasteride update/information on Penis/Penile Tissue

in Finasteride/Dutasteride 8 upvotes 3 years ago

Finasteride can reduce DHT in the genitalia, potentially causing side effects like reduced erections and penile fibrosis. Using PDE5 inhibitors like Tadalafil or Sildenafil may help maintain penile health and prevent fibrosis.

community Are these all the anti androgen products?

in Treatment 4 upvotes 2 years ago

The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

Related Research

6 / 6 results

research Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair

June 2023 in “Clinica Chimica Acta”

Finasteride and dutasteride effectively reduce DHT in hair, which may help evaluate their treatment success for hair loss.

research What Do We Know About 5-Alpha Reductase Inhibitors?

January 2018 in “Surgical and Cosmetic Dermatology”

5-alpha reductase inhibitors like finasteride and dutasteride are effective for treating enlarged prostate and male pattern hair loss.

research Dutasteride in Androgenetic Alopecia: An Update

27 citations , March 2017 in “Current Clinical Pharmacology”

Dutasteride is becoming a popular hair loss treatment, proving more effective than finasteride with similar side effects.

Dutasteride for Men with Androgenic Alopecia Unresponsive to Finasteride