Anti-androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium japonicum) I. Active Constituents Inhibiting Testosterone 5.ALPHA.-Reductase.
January 2002
in “Biological & Pharmaceutical Bulletin”
TLDR Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.
The study from 2002 examined the effects of Lygodii Spora extract on hair growth and its potential as an anti-androgenic agent. The extract was found to inhibit testosterone 5α-reductase in vitro, an enzyme linked to hair loss. In vivo, it reduced the growth of the flank organ in castrated Syrian hamsters and promoted hair regrowth in testosterone-treated C57Black/6CrSlc mice. The active compounds responsible for these effects were identified as oleic, linoleic, and palmitic acids. The in vivo experiments involved 6-8 hamsters and 8-10 mice, indicating that Lygodii Spora and its fatty acid components could be beneficial for treating androgen-related hair loss.
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research Anti-androgenic Activity of Myricae Cortex. Isolation of Active Constituents from Bark of Myrica rubra.
The bark of Myrica rubra contains compounds that can block testosterone effects and might help prevent hair loss.