Andrographolide Loaded Topical Nanocarriers for Management of Psoriasis: A Safe and Effective Approach

The document discussed the development of andrographolide-loaded topical nanocarriers as a potential treatment for psoriasis, a condition affecting over 125 million people globally. Traditional treatments like corticosteroids and biologics have limitations, prompting the exploration of safer alternatives such as andrographolide, a compound from Andrographis paniculata. However, its poor oral bioavailability posed challenges for conventional formulations. The study proposed using liposomes as nanocarriers to enhance delivery and efficacy, aiming to incorporate andrographolide into a lipid-based system for topical application. This approach was expected to improve targeting of diseased skin and reduce side effects associated with traditional therapies.