Androgens in Cervical Cancer: Their Role in Epidemiology and Biology

June 2024 in “ iScience ”

Yang Gu, Qing Mu, Dali Cheng

androgens androgen receptors HPV cervical cancer proliferation apoptosis ABCG2 cervical cancer stem cells immunotherapy androgen-targeting treatments

Studysummary This review highlights the significant role of androgens in the development and progression of cervical cancer, emphasizing the need for further research to understand their impact on the disease and improve prevention and treatment strategies in regions with limited HPV screening. Our plain-language summary of this paper — not a Tressless recommendation.

This review examines the role of androgens in cervical cancer, focusing on their impact on epidemiology and biological mechanisms. Androgens, present in both men and women, are linked to increased cervical cancer risk through their interaction with androgen receptors in cervical tissues, influencing processes like proliferation and apoptosis. They may also affect HPV-related cellular changes, a major risk factor for cervical cancer. The review highlights the need for further research to understand these interactions, which could lead to better prevention and treatment strategies, especially in regions with limited HPV screening. Additionally, the document discusses how androgens regulate key proteins and genes, such as ABCG2, enhancing cervical cancer stem cell survival, and their potential role in novel therapeutic approaches, including targeted immunotherapy and androgen-targeting treatments.

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