Androgenic Efficacy and Mechanism of Glycosides-Based Standardized Fenugreek Seeds Extract Through Aromatase and 5-Alpha Reductase Inhibition

    February 2024 in “ Pharmacognosy Journal ”
    Urmila Aswar, Savita Raju Nimse, Prasad Thakurdesai
    Image of study
    TLDR Fenugreek seed extract boosts testosterone and improves male reproductive health without heart side effects.
    The study investigated the androgenic efficacy of glycosides-based standardized fenugreek seed extract (SFSE-G) in male Wistar rats. Over 28 days, rats received oral doses of SFSE-G, which resulted in enhanced sexual behavior, increased weights of reproductive organs, higher serum testosterone levels, improved sperm count, and elevated penile nitric oxide concentration, while maintaining normal testis architecture. Additionally, SFSE-G significantly inhibited aromatase and 5-alpha-reductase enzymes in vitro. Acute intravenous administration of SFSE-G increased intracavernous pressure without affecting cardiovascular parameters. The findings suggest that SFSE-G has significant androgenic and spermatogenic effects through testosterone metabolism inhibition, without cardiovascular side effects.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 9 results

      community Redensyl for Hair Loss — What It Can and Can’t Do

      in Treatment 3 months ago
      Redensyl is a plant-based treatment that may support hair regrowth by reactivating dormant follicles and improving hair density, especially in early-stage thinning. It is not a miracle cure and results vary; it is less proven than Minoxidil or Finasteride and may cause scalp irritation.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community This serum outperformed Minoxidil in a recent study. Please debunk

       23 upvotes 6 years ago
      A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

      community Redensyl Megathread !!!!

       39 upvotes 6 years ago
      Redensyl, which is a topical alternative to Minoxidil for hair loss. It may have advantages such as not making the hair greasy and lasting longer after discontinuing use than minoxidil. There are some positive reports from users, but also some negative ones, so it's unclear how effective this treatment will be in comparison to Minoxidil and other treatments like Finasteride or RU58841.

      community Organic Self Tanner on bald Scalp?

      in Shaved/buzzed  1 upvotes 3 years ago
      The user is using topical minoxidil and finasteride, along with daily derma rolling, and is considering using an organic self-tanner on their shaved scalp. They seek advice on whether the self-tanner's ingredients could harm hair regrowth.

    Related Research

    3 / 3 results