Androgen Status in Patients with Androgenetic Alopecia

December 2015 in “ Вестник дерматологии и венерологии ”

И. Н. Кондрахина, А. Н. Мареева, Polina Kalinina, M. Abuladze

androgenetic alopecia testosterone dihydrotestosterone DHT 5-alpha reductase hair follicle regulation finasteride 5-alpha reductase inhibitor hormonal sensitivity genetic predisposition AGA Propecia

TLDR Men with male pattern baldness may not have different hormone levels, but their hair follicles are likely more sensitive to hormones.

The 2015 article examined the androgen hormone profile in males with androgenetic alopecia (AGA), focusing on the role of testosterone, dihydrotestosterone (DHT), and the enzyme 5-alpha reductase in hair follicle regulation and AGA pathogenesis. Studies reviewed showed inconsistent results regarding androgen levels in men with AGA, with some reporting no significant difference in testosterone levels compared to controls, and others noting an increased DHT to testosterone ratio. The article also discussed genetic predisposition and the hormonal sensitivity of hair follicles in AGA development, as well as the impact of finasteride, a 5-alpha reductase inhibitor, on hormone levels in younger men with AGA. The research indicated a lack of consensus on the importance of androgen levels in AGA, suggesting that the genetically determined sensitivity of hair follicles to hormones may be more relevant. Further research was deemed necessary to enhance AGA treatment.

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