Androgen Metabolism in Hirsute Patients Treated with Cyproterone Acetate

    March 1984 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”
    Irène Mowszowicz, Françoise Wright, M Vincens, Catherine Rigaud, K Nahoul, Philippe Mavier, S Guillemant, Frédérique Kuttenn, P Mauvais-Jarvis
    TLDR Cyproterone acetate effectively reduced hair growth in hirsute patients by lowering androgen levels and altering androgen metabolism.
    The study investigated the effects of cyproterone acetate (CPA) combined with estradiol on 150 hirsute patients over 6 months to 3 years, showing significant clinical improvement. Plasma testosterone (T) and androstenedione (A) levels decreased significantly, while T glucuronide (TG) and 3α-androstanediol (Adiol) levels remained high. T 5α-reductase activity in pubic skin also decreased. The study measured testosterone production rate (PR) and metabolic clearance rate (MCR) in 7 patients, finding a decrease in PR and an increase in MCR, explaining the plasma T concentration drop and high TG and Adiol excretion. CPA's mechanisms included reducing androgen input to target cells, competing for receptor binding sites, and decreasing androgen-dependent skin 5α-R, enhancing its antiandrogenic effect.
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      community Extreme regimen and still miniaturized hairs. AGA is just impossible to beat.

      in Insane  35 upvotes 3 years ago
      A user's extreme regimen for hair loss, which includes taking oral and topical medications such as minoxidil, dutasteride, cyproterone acetate and bicalutamide, but still experiencing miniaturization. Suggestions were made to try other treatments such as RU58841 and Pyrilutamide, while also considering mental health treatment and advice on lookmaxxing.

      community Regrowth after 9 months of DHT blockers, and 6 months of HRT

      in Transgender  24 upvotes 4 months ago
      A 20-year-old saw significant hair regrowth after 9 months of using DHT blockers (finasteride and dutasteride) and 6 months of hormone replacement therapy (HRT) with estradiol. The regrowth is attributed to low testosterone and high estradiol levels, without using Minoxidil.

      community Are these all the anti androgen products?

      in Treatment  6 upvotes 2 years ago
      The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

      community 5 months of nuking T, 2 months of minoxidil

      in Transgender  487 upvotes 1 year ago
      The user transitioned from finasteride to Cyproterone and started using Minoxidil, resulting in healthier hair and regrowth. They plan to wean off Minoxidil in a year, depending on regrowth.

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