TLDR A blood test level of 3.2 ng/mL of Antimüllerian hormone is good for identifying polycystic ovarian morphology in European women aged 25–45.
The APHRODITE study, a retrospective, multicenter, case-control study involving 2,014 participants, aimed to determine a cutoff for the Elecsys AMH Plus immunoassay to identify polycystic ovarian morphology (PCOM), a criterion for polycystic ovary syndrome (PCOS). The study found that a serum Antimüllerian hormone (AMH) cutoff of 3.2 ng/mL resulted in a sensitivity of 88.6% and specificity of 84.6% for PCOM diagnosis, with similar results across PCOS phenotypes A–D. The study concluded that the Elecsys AMH Plus immunoassay is a robust method for identifying PCOM to aid in PCOS diagnosis. The study also found that body mass index (BMI) and race had no significant effect on case-control status. The findings are generalizable to European women aged 25–45 years with symptoms suggestive of PCOS.
13 citations,
August 2018 in “Taiwanese Journal of Obstetrics & Gynecology” AMH is a good marker for diagnosing PCOS, but global standards are needed.
767 citations,
September 2016 in “Human Reproduction” Polycystic ovary syndrome affects about 6-10% of women, with varying symptoms and the need for standardized global definitions.
4809 citations,
January 2004 in “Fertility and Sterility” The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.
16 citations,
September 2018 in “Clinical Biochemistry” The document concludes that more research is needed to fully understand the causes of PCOS.
8 citations,
May 2021 in “Reproductive Biology and Endocrinology” Different levels of anti-Müllerian hormone can help diagnose polycystic ovary syndrome in women of different ages.
4 citations,
May 2022 in “BMC Women's Health” High levels of anti-Müllerian hormone can indicate polycystic ovarian syndrome in women who can have babies.
8 citations,
June 2016 in “Journal of Cosmetic Dermatology” Women with persistent acne and high levels of antimullerian hormone are more likely to have polycystic ovarian syndrome.
53 citations,
February 2022 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” AMH helps estimate ovarian reserve but doesn't predict pregnancy chances; age is more important.
