Treatment Of Alopecia Universalis In A Child With Down Syndrome

August 2023 in “ Indian journal of pediatrics/Indian Journal of Pediatrics ”

Evangeline Abenoja, Hanof Ahmed, Gomathy Sethuraman

alopecia universalis Down syndrome mometasone tacrolimus minoxidil topical therapy systemic agents hair regrowth Rogaine

TLDR Topical treatments helped a child with Down syndrome and severe hair loss regrow most of his hair.

A 2-year-old boy with Down syndrome (DS) experienced sudden-onset alopecia universalis (AU), losing hair across his entire body, including the scalp, eyebrows, and eyelashes. Traditional treatments for DS patients with AU often involve systemic agents, which can have variable responses and side effects. In this case, the child was treated with a combination of topical therapies: mometasone lotion 0.1%, tacrolimus ointment 0.03%, and minoxidil lotion 2%. This regimen resulted in 60% hair regrowth within four months and near-complete regrowth after six months. A minor relapse occurred when the frequency of application was reduced, but it was quickly resolved by returning to the alternate-day medication schedule. The child showed sustained improvement, indicating that combination topical therapy can be a safe, cost-effective, and efficacious treatment for severe AU in children with DS before considering systemic treatment options.

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Research cited in this study

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research Treatment of Alopecia Areata: An Australian Expert Consensus Statement

95 citations , November 2018 in “Australasian journal of dermatology”

Alopecia areata treatment varies, with no optimal method established yet.

research Treatment of Alopecia Universalis with Topical Janus Kinase Inhibitors – A Double Blind, Placebo, and Active Controlled Pilot Study

49 citations , August 2018 in “International Journal of Dermatology”

Topical JAK inhibitors may help treat alopecia universalis by promoting hair regrowth.

research Alopecia Areata in Down Syndrome: A Clinical Evaluation

22 citations , May 2005 in “Journal of the European Academy of Dermatology and Venereology”

People with Down syndrome are more likely to have alopecia areata and need regular skin check-ups.

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