Global, Regional, And National Burden Of Alopecia Areata And Its Associated Comorbidities, 1990–2021, And Projections To 2050: An Analysis Of The Global Burden Of Disease Study 2021

August 2025 in “ Acta Dermato Venereologica ”

Dan Wang, Peizhi Deng, Shengbo Yang, Yangfan Xu, Jianyun Lu

alopecia areata atopic dermatitis psychological disorders anxiety

TLDR Alopecia areata is decreasing globally, affects more females, and is linked to anxiety and atopic dermatitis, especially in children.

This study analyzed the global burden of alopecia areata from 1990 to 2021 across 204 countries, highlighting a decreasing trend in age-standardized prevalence, incidence, and years lived with disability, with a higher prevalence in females. The disease burden decreased in high sociodemographic index regions and was evenly distributed globally. Population growth and aging were major contributors to the burden. Alopecia areata before age 14 was linked to anxiety and psychological disorders, unlike cases after age 14. Additionally, atopic dermatitis was associated with alopecia areata, emphasizing the need for age-specific recognition of psychological impacts.

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Global, Regional, And National Burden Of Alopecia Areata And Its Associated Comorbidities, 1990–2021, And Projections To 2050: An Analysis Of The Global Burden Of Disease Study 2021

Research cited in this study

research Janus Kinase Inhibitors for Alopecia Areata

research Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population

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research Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels

research Alopecia Areata: A Multifactorial Autoimmune Condition

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