Global, Regional, And National Burden Of Alopecia Areata And Its Associated Comorbidities, 1990–2021, And Projections To 2050: An Analysis Of The Global Burden Of Disease Study 2021

August 2025 in “ Acta Dermato Venereologica ”

Dan Wang, Peizhi Deng, Shengbo Yang, Yangfan Xu, Jianyun Lu

alopecia areata atopic dermatitis psychological disorders anxiety

TLDR Alopecia areata is decreasing globally, affects more females, and is linked to anxiety and atopic dermatitis, especially in children.

The study analyzes the global burden of alopecia areata from 1990 to 2021 and projects trends to 2050, using data from 204 countries. It finds a decreasing trend in the age-standardized prevalence, incidence, and years lived with disability due to alopecia areata, with a higher prevalence in females. The disease burden has reduced in high sociodemographic index regions, but the condition is generally evenly distributed globally. Population growth and aging are major contributors to the disease burden. Alopecia areata in children under 14 is linked to anxiety and psychological disorders, unlike in older individuals. Additionally, atopic dermatitis is associated with alopecia areata, highlighting the need for age-specific recognition of psychological impacts.

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research Janus Kinase Inhibitors for Alopecia Areata

7 citations , August 2023 in “Journal of the American Academy of Dermatology”

JAK inhibitors offer new hope for treating severe alopecia areata.

research Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population

75 citations , March 2023 in “JAMA Dermatology”

Alopecia areata and its severe forms are becoming more common, especially among females, adults, and people in the Northeast.

research The Burden of Alopecia Areata: A Scoping Review Focusing on Quality of Life, Mental Health, and Work Productivity

10 citations , January 2023 in “Journal of the European Academy of Dermatology and Venereology”

Alopecia areata greatly affects people's life quality, mental health, and work life.

research Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels

11 citations , July 2022 in “Frontiers in immunology”

Cases of alopecia areata and its impact on life quality rose globally, but when adjusted for age, the rates decreased, especially in poorer regions.

research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , December 2018 in “Journal of autoimmunity”

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

research JAK Inhibitors for Treatment of Alopecia Areata

63 citations , July 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

JAK inhibitors can effectively reverse hair loss in people with alopecia areata.

research Alopecia Areata: Overview and Insights from January 2018

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

research Alopecia Areata: Treatment Options and Efficacy

182 citations , December 2017 in “Journal of the American Academy of Dermatology”

Some treatments can help with a hair loss condition called alopecia areata, but none ensure lasting results; choices depend on the person, with JAK inhibitors showing promise for severe cases.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.