Aged Skin Cells Nurture Stem Cells Toward Regeneration

October 2023 in “ Journal of Investigative Dermatology ”

Xiaojie Wang, Maksim V. Plikus

senescent cells secretory phenotype SASP hair growth hair follicle stem cells osteopontin osteopontin-CD44 signaling pathway senescent melanocytes senescent secretome factors

Studysummary Aged skin cells can help hair growth by stimulating stem cells.

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research Signaling by Senescent Melanocytes Hyperactivates Hair Growth

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In this study using genetic mouse models, researchers discovered that senescent melanocytes in nevi secrete osteopontin, which activates hair stem cells, enhancing hair growth; this process is mirrored in human hairy nevi, suggesting a potential therapeutic target for regenerative disorders.

research Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior

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This abstract omits specific findings and does not provide new research results.