Androgenetic Alopecia And Metabolic Syndrome: From Mechanisms To Treatment Strategies

July 2025 in “ Chinese Journal of Dermatology ”

androgenetic alopecia metabolic syndrome miniaturization of hair follicles hair growth phases abdominal obesity impaired glucose metabolism hypertension dyslipidemia AGA MetS

TLDR Hair loss and metabolic syndrome are linked, sharing causes and treatment options.

Androgenetic alopecia (AGA) is the most common form of hair loss, characterized by the miniaturization of scalp hair follicles and shortened hair growth phases. Recent research indicates a significant link between AGA and metabolic syndrome (MetS), which is marked by abdominal obesity, impaired glucose metabolism, hypertension, and dyslipidemia. This article reviews the epidemiological connection between AGA and MetS, investigates the shared mechanisms, and evaluates both current and potential treatment strategies.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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N-Acetyl-Cysteine (NAC) was found to improve hair parameters in men with early-onset androgenetic alopecia, showing increased terminal hair count and decreased vellus hair count, with good tolerability. NAC, used alone or with minoxidil, may help due to its antioxidant properties, though its effectiveness can vary among individuals.

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in Research/Science 42 upvotes 1 year ago

David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.

community The Cure isn't 5 years away; it's already here.

in Research/Science 1005 upvotes 10 months ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.

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The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

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