Editorial: Biomedical Advances in Ultrasound-Mediated Drug/Molecule Delivery

    August 2022 in “ Frontiers in Pharmacology
    Agata A. Exner, Jean‐Michel Escoffre
    TLDR Ultrasound can improve targeted drug delivery, making treatments more effective with fewer side effects.
    This editorial discussed the challenges and advancements in ultrasound (US)-mediated drug delivery, particularly in overcoming biological barriers that impede therapeutic efficacy. It highlighted the potential of US-responsive particles, like microbubbles, to enhance drug delivery in a non-invasive manner, with promising pre-clinical results. The research included contributions on bactericidal therapy, alopecia, cancer, and gene therapy, emphasizing the development of minoxidil-coated lysozyme-shelled microbubbles for improved hair growth and infection control. The studies demonstrated increased drug penetration and effectiveness, supporting the clinical translatability of these methods. The editorial concluded that while progress was made, further development of US-sensitive drug carriers was necessary to meet clinical needs.
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