Advancements in Bioactive Compounds and Therapeutic Agents for Alopecia: Trends and Future Perspectives

December 2025 in “ Cosmetics ”

Eunmiri Roh

alopecia areata androgenetic alopecia baricitinib ritlecitinib dihydrotestosterone follicular miniaturization minoxidil platelet-rich plasma intracellular signaling pathways stem cell organoids exosome-based therapeutics microbial homeostasis mitochondrial homeostasis AA AGA DHT Rogaine PRP

This review discusses recent advancements in the treatment of alopecia, focusing on alopecia areata (AA) and androgenetic alopecia (AGA). It highlights the role of immune and hormonal factors in these conditions and the potential of selective inhibitors like baricitinib and ritlecitinib to restore immune balance in AA. For AGA, the review emphasizes the impact of dihydrotestosterone on follicular miniaturization and the benefits of combination therapies, including low-dose oral minoxidil and platelet-rich plasma, in promoting hair regrowth. The paper also explores the significance of intracellular signaling pathways and the potential of stem cell organoids and exosome-based therapeutics in advancing treatment from mere suppression to structural follicle reconstruction. Additionally, it underscores the importance of maintaining microbial and mitochondrial homeostasis for effective and lasting hair regeneration.

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