Activation of β-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth

    July 2016 in “PLOS ONE
    Linli Zhou, Mingang Xu, Yunxia Yang, Kun Yang, R. Randall Wickett, Thomas Andl, Sarah E. Millar, Yuhang Zhang
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    TLDR Activating β-catenin in certain skin cells speeds up hair growth in mice.
    The study explored the effect of β-catenin signaling activation in CD133-positive dermal papilla (DP) cells on hair growth in mice. It was found that activating β-catenin in these cells significantly accelerated hair growth without affecting the regression phase of the hair cycle. The activation led to increased proliferation and differentiation of epithelial matrix keratinocytes and a larger population of proliferating DP cells. The research suggests that β-catenin signaling could be a potential therapeutic target for hair growth disorders. Although the study used a tri-transgenic mouse model, the specific number of mice used was not mentioned in the summary. The findings indicate that CD133+ DP cells contribute to hair growth after the onset of the anagen phase and that β-catenin signaling promotes hair follicle differentiation and growth during the early-to-mid anagen stages. However, the secreted factors involved in this process were not fully characterized and require further investigation.
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