A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes<i>in vitro</i>and<i>in situ</i>

February 2013 in “ PeerJ ”

Yuval Ramot, Koji Sugawara, Nóra Zákány, Balázs István Tóth, Tamás Bı́ró, Ralf Paus

cannabinoid receptor 1 CB1 keratin keratins K6 keratins K16 psoriasis ACEA AM251 keratinocytes CB1 antagonist CB1 agonist

TLDR Activating cannabinoid receptor 1 reduces certain keratin levels, potentially aiding psoriasis treatment.

The study explored the role of cannabinoid receptor 1 (CB1) in regulating keratin expression in human skin, particularly focusing on keratins K6 and K16, which are up-regulated in psoriasis. Researchers found that activating CB1 with the agonist ACEA reduced the expression of K6 and K16 in human skin and cultured keratinocytes, effects that were partially reversed by the CB1 antagonist AM251. This reduction in keratin expression was independent of CB1's anti-proliferative effects on keratinocytes. The findings suggested that CB1-mediated signaling could be a novel mechanism for controlling keratin expression, with potential implications for psoriasis treatment and wound healing.

View this study on peerj.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Endocannabinoids Limit Excessive Mast Cell Maturation And Activation In Human Skin

124 citations , January 2012 in “Journal of Allergy and Clinical Immunology”

Endocannabinoids help control mast cell activity in human skin.

research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions

61 citations , July 2011 in “PLOS ONE”

Spermidine may help reduce hair loss and deserves further testing as a treatment.

Thyrotropin-Releasing Hormone and Estrogen Differentially Regulate Prolactin and Prolactin Receptor Expression in Female Human Skin and Hair Follicles In Vitro

research Thyrotropin-Releasing Hormone and Estrogen Differentially Regulate Prolactin and Prolactin Receptor Expression in Female Human Skin and Hair Follicles In Vitro

37 citations , March 2010 in “British Journal of Dermatology”

Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.

research Thyroid-Stimulating Hormone, a Novel, Locally Produced Modulator of Human Epidermal Functions, Is Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones

105 citations , February 2010 in “Endocrinology”

The study demonstrated that normal human epidermis expressed thyroid-stimulating hormone (TSH) at both mRNA and protein levels and transcribed TSH receptors (TSH-R). It was found that intraepidermal TSH expression was up-regulated by thyrotropin-releasing hormone (TRH) and down-regulated by thyroid hormones. Although TSH-R immunoreactivity was not observed within the epidermis, it was present in the adjacent dermis. TSH treatment in organ-cultured human skin significantly increased the expression of epidermal proteins such as involucrin, loricrin, and keratins 5 and 14. This suggested that the epidermis acted as both a source and a target of TSH signaling, regulated by the same endocrine controls as the hypothalamic-pituitary-thyroid axis.

research Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ

64 citations , January 2010 in “The FASEB Journal”

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

research The ‘melanocyte-keratin’ mystery revisited: neither normal human epidermal nor hair follicle melanocytes express keratin 16 or keratin 6in situ

8 citations , June 2009 in “British Journal of Dermatology”

Human melanocytes in skin and hair follicles don't express keratin 16 or 6 naturally.

research The human keratins: biology and pathology

1398 citations , May 2008 in “Histochemistry and Cell Biology”

Keratins are crucial for cell stability, wound healing, and cancer diagnosis.

research Keratins of the Human Hair Follicle

276 citations , January 2005 in “International review of cytology”

Similar Research

5 / 227 results

research Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases?

26 citations , May 2014 in “BioEssays”

Using neurohormones to control keratin can lead to new skin disease treatments.

research Peer Review #2 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"

February 2013

Activating CB1 can reduce keratin levels, potentially helping manage psoriasis and aid wound healing.

research Peer Review #1 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"

February 2013

Activating cannabinoid receptor 1 may help manage psoriasis by reducing certain keratins.

Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

research Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

14 citations , February 2021 in “Experimental Dermatology”

Cannabinoid receptor-1 signaling is essential for the survival and growth of human hair follicle stem cells.

research Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases

3 citations , December 2022 in “Cells”

Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.

A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes<i>in vitro</i>and<i>in situ</i>

Research cited in this study

research Endocannabinoids Limit Excessive Mast Cell Maturation And Activation In Human Skin

research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions

research Thyrotropin-Releasing Hormone and Estrogen Differentially Regulate Prolactin and Prolactin Receptor Expression in Female Human Skin and Hair Follicles In Vitro

research Thyroid-Stimulating Hormone, a Novel, Locally Produced Modulator of Human Epidermal Functions, Is Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones

research Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ

research The ‘melanocyte-keratin’ mystery revisited: neither normal human epidermal nor hair follicle melanocytes express keratin 16 or keratin 6in situ

research The human keratins: biology and pathology

research Keratins of the Human Hair Follicle

Related Community Posts Join

community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

community My microneedling journey (no min, fin, etc)

community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

community About the CBD regrowth study : just a few remarks

community 11mth daily 0.5mg oral finasteride