Dihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines

    September 2020 in “ OncoTargets and Therapy ”
    Dulce Carolina Rodríguez-Lozano, Daniel Velázquez-Vázquez, Aylin Del Moral-Morales, Ignacio Camacho-Arroyo
    Studysummary This study found that testosterone may promote glioblastoma progression by being converted into dihydrotestosterone, which enhances cell proliferation, migration, and invasion in GBM cell lines.
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    Research cited in this study 12

    1. The Effect of Finasteride and Dutasteride on the Synthesis of Neurosteroids by Glioblastoma Cells Steroids · 2019
    2. 5-Alpha Reductase Inhibitors and Risk of Male Breast Cancer: A Systematic Review and Meta-Analysis International Braz J Urol · 2018
    3. Do 5α-Reductase Inhibitors Raise Circulating Serum Testosterone Levels? A Comprehensive Review and Meta-Analysis Explaining Paradoxical Results Sexual Medicine Reviews · 2018
    4. Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2018
    5. Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells International journal of molecular sciences · 2018
    6. Allopregnanolone Promotes Proliferation and Differential Gene Expression in Human Glioblastoma Cells Steroids · 2017
    7. Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials The Journal of Sexual Medicine · 2016
    8. Finasteride Inhibits Human Prostate Cancer Cell Invasion Through MMP2 And MMP9 Downregulation PLoS ONE · 2013
    9. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    10. Differential Expression of Steroid 5α-Reductase Isozymes and Association with Disease Severity and Angiogenic Genes Predict Their Biological Role in Prostate Cancer Endocrine Related Cancer · 2010
    11. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    12. Estimating the Contribution of the Prostate to Blood Dihydrotestosterone ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2003