Gene Detection in a Family With Monilethrix and Observation of the Treatment Effect With 5% Topical Minoxidil

    September 2022 in “ Research Square (Research Square) ”
    Qingli Shen, Zhong-Hua Fu, Pengqiang Du, Jianbo Wang

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that a specific gene mutation was identified in a family with monilethrix, and treatment with 5% minoxidil liniment improved hair quality in the proband without adverse events.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 8

    1. Autosomal Recessive Monilethrix: Novel Variants of the DSG4 Gene in Three Chinese Families Molecular genetics & genomic medicine · 2022
    2. Treatment of Monilethrix with Oral Minoxidil JAAD case reports · 2016
    3. Monilethrix: A Typical Case Report with Microscopic and Dermatoscopic Findings Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2015
    4. Monilethrix Treated with Minoxidil International Journal of Immunopathology and Pharmacology · 2011
    5. A Missense Mutation in the Type II Hair Keratin hHb3 Is Associated with Monilethrix Journal of Medical Genetics · 2005
    6. Monilethrix: Mutational Hotspot in the Helix Termination Motif of the Human Hair Basic Keratin 6 Human Heredity · 2000
    7. A Mutational Hotspot in the 2B Domain of Human Hair Basic Keratin 6 (hHb6) in Monilethrix Patients Journal of Investigative Dermatology · 1998
    8. A New Mutation in the Type II Hair Cortex Keratin hHb1 Involved in the Inherited Hair Disorder Monilethrix Human Genetics · 1997