GJB6 Missense Variant in a Labrador Retriever With Paw Pad Hyperkeratosis

January 2026 in “ Animal Genetics ”

Stefan J. Rietmann, Joseph Malatos, Vidhya Jagannathan, Tosso Leeb

GJB6 connexin 30 desmosome Clouston syndrome alopecia palmoplantar hyperkeratosis

Studysummary This study investigated a Labrador Retriever with paw pad hyperkeratosis and identified a unique de novo heterozygous missense variant in the GJB6 gene, suggesting its potential role in the condition, analogous to Clouston syndrome in humans, although differences between species may provide further insights.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

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