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GlossaryPalmoplantar Keratoderma

thickening of skin on palms and soles

Palmoplantar Keratoderma (PPK) is a group of skin conditions characterized by the thickening of the skin on the palms of the hands and the soles of the feet. This thickening, known as hyperkeratosis, can be either inherited or acquired and may cause discomfort, pain, or difficulty in movement.

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DSP c.6310delA p.(Thr2104Glnfs*12) Associates With Arrhythmogenic Cardiomyopathy, Increased Trabeculation, Curly Hair, and Palmoplantar Keratoderma

research DSP c.6310delA p.(Thr2104Glnfs*12) Associates With Arrhythmogenic Cardiomyopathy, Increased Trabeculation, Curly Hair, and Palmoplantar Keratoderma

1 citations , March 2023 in “Frontiers in Cardiovascular Medicine”

A specific gene variant is linked to heart disease, increased heart muscle, curly hair, and thick skin on palms and soles.

research The Spectrum of Cutaneous Adverse Events During Encorafenib and Binimetinib Treatment in B-Rapidly Accelerated Fibrosarcoma-Mutated Advanced Melanoma

21 citations , November 2018 in “Journal of the European Academy of Dermatology and Venereology”

The combination of encorafenib and binimetinib caused few skin issues.

research Prospective Case Series of Cutaneous Adverse Effects Associated With Dabrafenib and Trametinib

10 citations , September 2016 in “Journal of cutaneous medicine and surgery”

Patients on dabrafenib and trametinib for melanoma often experience skin side effects.

Clouston Syndrome: Report of a Jordanian Family with GJB6 Gene Mutation

research Clouston Syndrome: Report of a Jordanian Family with GJB6 Gene Mutation

October 2023 in “Case reports in dermatological medicine”

A Jordanian family with Clouston syndrome has a common GJB6 gene mutation.

IL-17 Axis Is a Significant Driver of Skin Inflammation in CARD14 Mutant Pityriasis Rubra Pilaris Model Mice

research IL-17 Axis Is a Significant Driver of Skin Inflammation in CARD14 Mutant Pityriasis Rubra Pilaris Model Mice

February 2023 in “Research Square (Research Square)”

Blocking IL-17 can reduce skin inflammation in a mouse model of pityriasis rubra pilaris.

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