CDK9 Kinase Activation in Association with AFF1-SEC Initiates Epidermal Progenitor Differentiation

November 2022 in “ Journal of Investigative Dermatology ”

S. Lloyd, Xiaomin Bao

NCSTN gene Hidradenitis Suppurativa skin organoids induced pluripotent stem cells CRISPR-Cas9 RNA-seq keratinocyte proliferation keratinocyte differentiation inflammatory cytokines inflammatory chemokines IL1a IL18 CCL20 S100A7 hair follicle stem cell differentiation HS iPSCs CRISPR

Studysummary This study reported that an HS-associated NCSTN mutation in iPSC-derived skin organoids led to altered hair follicle stem cell differentiation and increased expression of proteins linked to HS inflammation.

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