Generating Mouse Models of Degenerative Diseases Using Cre/Lox-Mediated In Vivo Mosaic Cell Ablation
May 2011
in “
Journal of Clinical Investigation
”
Studysummary In this study, a transgenic mouse model was used to demonstrate that targeted cell loss in different tissues led to varying degrees of regenerative outcomes, including reversible impaired glucose tolerance, irreversible hair loss, and permanent moderate deafness.
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