Cardiovascular Safety Signals of Oral Versus Topical Minoxidil in FAERS: A Disproportionality Analysis (Analytic Cohort 2012–2025)

    March 2026 in “ Life ”
    Hima Bindu Makkena, Vikas Kasu
    Studysummary This study found that oral minoxidil is associated with a higher proportional reporting of several cardiovascular adverse events compared to topical minoxidil in spontaneous FDA reports, but these signals should be interpreted as hypothesis-generating rather than evidence of clinical safety.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 9

    1. Low-Dose Oral Minoxidil and Associated Adverse Events: Analyses of the FDA Adverse Event Reporting System With a Focus on Pericardial Effusions Journal of Cosmetic Dermatology · 2024
    2. Evaluation of Pericardial Effusions in Alopecia Patients on Low-Dose Oral Minoxidil Therapy Journal of Drugs in Dermatology · 2024
    3. Efficacy and Safety of Low-Dose Oral Minoxidil in the Management of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2024
    4. Increased Interest in Oral Minoxidil for Hair Loss Treatment Following Publication of August 2022 New York Times Article: A Google Trends Analysis Skin appendage disorders · 2023
    5. Pericardial, Pleural Effusion and Anasarca: A Rare Complication of Low-Dose Oral Minoxidil for Hair Loss JAAD case reports · 2022
    6. Serious Adverse Effects From Compounding Errors With Low-Dose Oral Minoxidil for Alopecia Treatment Actas Dermo-Sifiliográficas · 2022
    7. Coming Full Circle (Almost): Low Dose Oral Minoxidil for Alopecia Journal of The American Academy of Dermatology · 2021
    8. Low-Dose Oral Minoxidil for Treating Alopecia: A 3-Year North American Retrospective Case Series Journal of The American Academy of Dermatology · 2020
    9. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020