The Association Between rs2476601 Polymorphism in PTPN22 Gene and Risk of Alopecia Areata
May 2019
in “
Medicine
”
New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide → Studysummary This meta-analysis found that the rs2476601 SNP of the PTPN22 gene is significantly associated with reduced susceptibility to alopecia areata, with carriers of the C-allele and CC-genotype having a lower risk.
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The study investigated the association between the rs2476601 polymorphism in the PTPN22 gene and the risk of developing alopecia areata (AA) through a meta-analysis of 5 case-control studies involving 1,129 AA patients and 1,702 healthy controls. The findings indicated that the rs2476601 SNP was significantly associated with AA susceptibility, with carriers of the C-allele and CC-genotype having a lower risk of developing AA. Despite limitations such as a limited number of studies, potential publication bias, and a predominance of Caucasian populations, the study provided valuable insights into the genetic underpinnings of AA and suggested the need for further large-scale, multi-center studies across different ethnicities.
