Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

August 2006 in “ Molecular and Cellular Biology ”

Maria Kasper, Harald Schnidar, Graham W. Neill, Michaela Hanneder, Stefan Klingler, Leander Blaas, Carmen Schmid, Cornelia Hauser‐Kronberger, Gerhard Regl, Michael P. Philpott, Fritz Aberger

Epidermal Growth Factor EGF Hedgehog/GLI pathway keratinocytes gene expression skin cell behavior

Studysummary This study found that EGFR signaling modulates GLI target gene expression, potentially influencing outer root sheath cell specification and hair growth, and may have implications for cancer.

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research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway

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This study found that a topical hedgehog agonist can stimulate hair growth by promoting the transition from the resting to growth phase of the hair cycle in adult mouse skin.

research GLI2 Is Expressed in Normal Human Epidermis and Basal Cell Carcinoma and Induces GLI1 Expression by Binding to Its Promoter

171 citations , June 2004 in “Journal of Investigative Dermatology”

GLI2 activates GLI1, promoting skin tumor growth and hair development.

research FOXE1, A New Transcriptional Target Of GLI2, Is Expressed In Human Epidermis And Basal Cell Carcinoma

92 citations , May 2004 in “Journal of Investigative Dermatology”

research Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1

380 citations , March 2000 in “Proceedings of the National Academy of Sciences”

This study demonstrates that mice with ectopic expression of the human GLI-1 gene in their skin developed tumors resembling human basal cell carcinoma, suggesting that GLI-1 is central to tumor development without additional p53 or Ha ras mutations.

research Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1

333 citations , March 2000 in “Proceedings of the National Academy of Sciences”

In this study, researchers established that increased expression of the human GLI-1 gene in mouse skin leads to the development of tumors that closely resemble human basal cell carcinomas, without requiring additional mutations in the p53 or Ha ras genes.

research Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors

638 citations , October 1997 in “Nature”

research Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development

107 citations , June 1997 in “PubMed”

In this study, disrupting the epidermal growth factor receptor in mice led to abnormal hair and skin development, characterized by disorganized hair follicles and systemic disease, providing a model for understanding EGFR's role in skin biology.

research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations , February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study concluded that epidermal growth factor may induce a 'catagen-like' phase in human hair follicles by disrupting normal cellular proliferation and migration patterns.

research IL-1 Alpha Inhibits Human Hair Follicle Growth And Hair Fiber Production In Whole-Organ Cultures

30 citations , August 1993 in “PubMed”

This study found that IL-1 alpha inhibits the growth of cultured human hair follicles and hair fibers, suggesting a potential role in inflammatory hair loss conditions like alopecia areata.