Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and Delta-Subunit-Containing Gamma-Aminobutyric Acid A Receptors

November 2018 in “ The journal of pain/Journal of pain ”

Xuhui Chen, Zuofan Li, Bo Zhang, Rong Hu, Jiayan Li, Miaomiao Feng, Wenlong Yao, Chuanhan Zhang, Li Wan, Yue Zhang

finasteride dutasteride allopregnanolone steroidogenic acute regulatory protein 14,15-epoxyeicosatrienoic acid δGABAAR bicuculline gabapentin Propecia Avodart AP 14,15-EET delta-GABAAR

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Studysummary This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.

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