Mettl3-Catalyzed m6A Regulates Histone Modifier and Modification Expression in Self-Renewing Somatic Tissue

    September 2023 in “ Science Advances ”
    Alexandra M. Maldonado López, Eun Kyung Ko, Sijia Huang … Brian C. Capell
    Studysummary In this study, deleting the gene Mettl3 in mouse epidermal progenitors resulted in impaired epithelial development and self-renewal, highlighting m<sup>6</sup>A's crucial role in regulating chromatin modifiers and maintaining normal epithelial tissue function.
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    Research cited in this study 4

    1. Life Before and Beyond Blistering: The Role of Collagen XVII in Epidermal Physiology Experimental Dermatology · 2018
    2. Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis eLife · 2017
    3. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    4. Principles of Hair Cycle Control The Journal of Dermatology · 1998