Genetic Architecture of Mouse Skin Inflammation and Tumor Susceptibility

    January 2009 in “ Nature ”
    David A. Quigley, Minh D. To, Jesus Perez-Losada … Allan Balmain
    Studysummary This study identified gene expression patterns in a mouse model that may influence tumor susceptibility and tissue functions related to inflammation and cell proliferation, highlighting Lgr5 and the vitamin D receptor as key regulators.
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    Research cited in this study 2

    1. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    2. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007