Effects of Sex Steroid Hormones and Their Metabolites on Neuronal Injury Caused by Oxygen-Glucose Deprivation/Reoxygenation in Organotypic Hippocampal Slice Cultures

    July 2016 in “ Steroids ”
    Yasuhiro Ishihara, Noriko Fujitani, Hikaru Sakurai … Takeshi Yamazaki
    Studysummary In this study using rat hippocampal cultures, progesterone and testosterone showed neuroprotective effects against oxygen-glucose deprivation-induced neuronal cell death, while metabolism of these hormones in the brain may affect their protective actions.
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    Research cited in this study 2

    1. Allopregnanolone-Mediated Protective Effects of Progesterone on Tributyltin-Induced Neuronal Injury in Rat Hippocampal Slices The Journal of Steroid Biochemistry and Molecular Biology · 2012
    2. Investigation of the Mechanisms of Progesterone Protection Following Oxygen-Glucose Deprivation in Organotypic Hippocampal Slice Cultures Neuroscience Letters · 2011

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