Stem and Cancer Cells Wnt Long Telomeres

August 2012 in “ Nature Cell Biology ”

Emily J. Chenette

Wnt-ß-catenin pathway telomerase TERT ß-catenin mouse embryonic stem cells chromatin remodeling factors RNA polymerase II adult intestinal stem cells primary neurospheres intestinal hyperplasia human embryonal carcinoma colorectal carcinoma hTERT Wnt-beta-catenin pathway beta-catenin stem cells chromatin remodeling RNA polymerase intestinal stem cells neurospheres embryonal carcinoma colorectal cancer

Studysummary This study provides direct evidence that the Wnt-β-catenin pathway promotes TERT expression in stem and cancer cells, linking tumorigenesis with pluripotency.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

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In this study, enteroendocrine cells were shown to coordinate intestinal stem cell migration towards a wound in Drosophila by releasing a ligand that activates non-canonical Wnt signaling, aiding efficient tissue repair.